A deeper dive into the real-world consequences of reducing mitigation protections in the face of waning immunity and more immune evasive and suppressive variants.
"Compared to a waned third dose, fourth dose VE was 13.1% (95% CI 0.9 to 23.8) overall; 24.0% (95% CI 8.5 to 36.8) in the first 2 months post-vaccination, reducing to 10.3% (95% CI −11.4 to 27.8) and 1.7% (95% CI −17.0 to 17.4) at 2–4 and 4–6 months, respectively."
"Relative to an infection >2 years ago and controlling for vaccination, 63.6% (95% CI 46.9 to 75.0) and 29.1% (95% CI 3.8 to 43.1) greater protection against infection was estimated for an infection within the past 0–6, and 6–12 months, respectively."
There are about 100,000 schools in the US. I think $10,000/year per school would cover the cost of buying and operating one HEPA H13 air purifier per classroom. That would be $1 billion per year for the US. That's a lot of money, but it might help.
More sensitive home test kits would be a huge help. The false negatives aren't helpful.
"Compared to a waned third dose, fourth dose VE was 13.1% (95% CI 0.9 to 23.8) overall; 24.0% (95% CI 8.5 to 36.8) in the first 2 months post-vaccination, reducing to 10.3% (95% CI −11.4 to 27.8) and 1.7% (95% CI −17.0 to 17.4) at 2–4 and 4–6 months, respectively."
"Relative to an infection >2 years ago and controlling for vaccination, 63.6% (95% CI 46.9 to 75.0) and 29.1% (95% CI 3.8 to 43.1) greater protection against infection was estimated for an infection within the past 0–6, and 6–12 months, respectively."
(Published:December 13, 2023)
https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(23)00228-4/fulltext
There are about 100,000 schools in the US. I think $10,000/year per school would cover the cost of buying and operating one HEPA H13 air purifier per classroom. That would be $1 billion per year for the US. That's a lot of money, but it might help.
More sensitive home test kits would be a huge help. The false negatives aren't helpful.