This research may explain why repeated vaccinations with boosters can increase your risk of infection. If I interpret it correctly, repeated booster vaccinations train your immune system to tolerate the virus much like allergy shots train your immune system to tolerate the allergen. Of course, an allergen isn't a rapidly replicating pathogen.
The latest data doesn't show any of the T-cell responses, only antibodies. Antibodies are evaded by the XBB variants so we depend on the T-cell response. We need more data to say one way or another but it has been shown to be less likely, but still possible, to cause an autoimmune response. The problem vaccine makers are encountering is that the virus is evolving beyond the vaccines and treatments as fast as they put them out. With the evolution moving so rapidly they can't predict what to target. They need to reassess and come up with a better strategy. The only way we will get ahead of it is if we reduce the level of transmission. Ventilation and Filtration of the air in schools should be the top priority but it isn't even being discussed.
NVX-CoV2373 Overview
"Lower neutralizing responses observed for BQ.1.1 and XBB.1 variants due to
mutations in conserved epitopes
Breadth of immune response against future-drift variants makes Novavax
technology an appealing choice for future annual vaccination campaigns
▪ Boosting data indicate comparable performance to currently available vaccines
▪ Prepared to deliver recommended monovalent or bivalent vaccines for the
What you write here for a booster dose of an extinct virus would also apply to the annual flu shot no? With proper precautions, your chances of getting the flu are virtually eliminated. Should you expend whatever T-cells you have for protection against a flu virus which is preventable by using respiratory protection?
Hi TACT...
This research may explain why repeated vaccinations with boosters can increase your risk of infection. If I interpret it correctly, repeated booster vaccinations train your immune system to tolerate the virus much like allergy shots train your immune system to tolerate the allergen. Of course, an allergen isn't a rapidly replicating pathogen.
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020844/full
Any data on Novavax vs the bi-valent booster? It wasn't updated, and until XBB the company claimed it was still protective.
The latest data doesn't show any of the T-cell responses, only antibodies. Antibodies are evaded by the XBB variants so we depend on the T-cell response. We need more data to say one way or another but it has been shown to be less likely, but still possible, to cause an autoimmune response. The problem vaccine makers are encountering is that the virus is evolving beyond the vaccines and treatments as fast as they put them out. With the evolution moving so rapidly they can't predict what to target. They need to reassess and come up with a better strategy. The only way we will get ahead of it is if we reduce the level of transmission. Ventilation and Filtration of the air in schools should be the top priority but it isn't even being discussed.
NVX-CoV2373 Overview
"Lower neutralizing responses observed for BQ.1.1 and XBB.1 variants due to
mutations in conserved epitopes
Breadth of immune response against future-drift variants makes Novavax
technology an appealing choice for future annual vaccination campaigns
▪ Boosting data indicate comparable performance to currently available vaccines
▪ Prepared to deliver recommended monovalent or bivalent vaccines for the
2023/24 vaccination season"
https://www.fda.gov/media/164812/download
What you write here for a booster dose of an extinct virus would also apply to the annual flu shot no? With proper precautions, your chances of getting the flu are virtually eliminated. Should you expend whatever T-cells you have for protection against a flu virus which is preventable by using respiratory protection?